Abstract |
Natural killer (NK) cells are spontaneously cytotoxic against tumour target cells. Their number was found to be four times more in the spleen of tumour-bearing Swiss albino mice. After activation with recombinant interleukin-2 (rIL-2), NK cells were tested and found to seek out the tumour site when injected intravenously in tumour-bearing mice. Their potential for fighting tumours in vivo was further seen following adoptive transfer of rIL-2 activated NK (A-NK) cells in tumour-bearing mice. After surgical removal of tumour load, adoptive transfer of A-NK cells inhibited tumour recurrence in 92.3%cases, thereby suggesting the use of this protocol for therapeutic purposes to obtain a better outcome.
|
Authors | Anuradha Rai, Ashim K Chakravarty |
Journal | Journal of biosciences
(J Biosci)
Vol. 32
Issue 7
Pg. 1299-305
(Dec 2007)
ISSN: 0250-5991 [Print] India |
PMID | 18202454
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Animals
- Fibrosarcoma
(immunology, therapy)
- Immunotherapy, Adoptive
- Interleukin-2
(immunology)
- Killer Cells, Natural
(immunology)
- Mice
- Secondary Prevention
- Time Factors
|