Abstract | BACKGROUND: AIM: To investigate the effect of dietary advice and lipid-lowering drugs, particularly statins, on patients with NAFLD and dyslipidaemia. DESIGN: Observational records based study. METHODS: RESULTS: Thirty-seven male and 34 female patients with NAFLD and dyslipidaemia were followed up for a mean period of 440 +/- 374 days (median 335). Regression analysis revealed a significant association between changes in weight and changes in serum ALT (p < 0.039). Dietary advice failed to reduce body weight but significantly lowered the serum cholesterol to HDL ratio (p = 0.05). Only 15.4% of patients taking statins experienced a rise in serum ALT > or = 40 U/l, and in each case the rise was transient, returning near baseline or below without discontinuation of statin treatment. CONCLUSIONS:
Weight loss appears to improve NAFLD, and dietary advice and lipid-lowering drugs may be beneficial for patients with NAFLD and dyslipidaemia even if weight loss is not achieved. Statins appear to be safe and efficacious in this group.
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Authors | P Riley, D Sudarshi, M Johal, A Benedict, J Panteli, M Crook, J O'Donohue |
Journal | International journal of clinical practice
(Int J Clin Pract)
Vol. 62
Issue 3
Pg. 374-81
(Mar 2008)
ISSN: 1368-5031 [Print] India |
PMID | 18201181
(Publication Type: Journal Article)
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Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Lipids
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(blood)
- Cohort Studies
- Dyslipidemias
(diet therapy, drug therapy)
- Fatty Liver
(diet therapy, drug therapy)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(adverse effects, therapeutic use)
- Life Style
- Lipids
(blood)
- Male
- Middle Aged
- Regression Analysis
- Retrospective Studies
- Treatment Outcome
- Weight Loss
(physiology)
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