Abstract | OBJECTIVE: STUDY DESIGN: Retrospective study. SETTING: Tertiary referral neurotology clinic. PATIENTS: INTERVENTION: MAIN OUTCOME MEASURE: A Kaplan-Meier time-to-event method was used to determine the rate of "survival," meaning sufficient satisfaction with vertigo control that the subject did not wish to have subsequent ablative treatment. "Failure" was defined as poor control and the choice to proceed to ablative treatment. RESULTS: CONCLUSION: IT dexamethasone injection therapy on an as-needed outpatient basis can provide vertigo control that is satisfactory in patients with Ménière's disease. The Kaplan-Meier method addresses the need for an outcome measure suited to repeated treatments and variable lengths of follow-up. However, due to the retrospective nature of this study, the presence of bias caused by loss of subjects from follow-up cannot be ruled out.
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Authors | Maria Soledad Boleas-Aguirre, Frank R Lin, Charles C Della Santina, Lloyd B Minor, John P Carey |
Journal | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
(Otol Neurotol)
Vol. 29
Issue 1
Pg. 33-8
(Jan 2008)
ISSN: 1531-7129 [Print] United States |
PMID | 18199956
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Inflammatory Agents
- Gentamicins
- Dexamethasone
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Audiometry
- Dexamethasone
(administration & dosage, therapeutic use)
- Drug Resistance
- Follow-Up Studies
- Gentamicins
(therapeutic use)
- Humans
- Injections
- Longitudinal Studies
- Meniere Disease
(drug therapy)
- Retrospective Studies
- Survival Analysis
- Treatment Failure
- Treatment Outcome
- Tympanic Membrane
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