Abstract | BACKGROUND: Experimental and human studies demonstrate that long-term exposure to elevated aldosterone levels results in cardiac and vascular damage. METHODS: We investigated long-term cardiovascular outcomes in patients with primary aldosteronism after surgical or medical treatment. Fifty-four patients with or without evidence of adrenal adenomas were prospectively followed up for a mean of 7.4 years after treatment with adrenalectomy or spironolactone. Patients with primary aldosteronism were compared with patients with essential hypertension and were treated to reach a blood pressure of less than 140/90 mm Hg. The main outcome measure was a combined cardiovascular end point comprising myocardial infarction, stroke, any type of revascularization procedure, and sustained arrhythmias. RESULTS: CONCLUSION: Primary aldosteronism is associated with a cardiovascular complication rate out of proportion to blood pressure levels that benefits substantially from surgical and medical treatment in the long term.
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Authors | Cristiana Catena, GianLuca Colussi, Elisa Nadalini, Alessandra Chiuch, Sara Baroselli, Roberta Lapenna, Leonardo A Sechi |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 168
Issue 1
Pg. 80-5
(Jan 14 2008)
ISSN: 0003-9926 [Print] United States |
PMID | 18195199
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Mineralocorticoid Receptor Antagonists
- Spironolactone
- Aldosterone
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Topics |
- Adrenalectomy
- Adult
- Aged
- Aldosterone
(blood)
- Cardiovascular Diseases
(blood, etiology)
- Female
- Follow-Up Studies
- Humans
- Hyperaldosteronism
(complications, therapy)
- Hypertension
(complications)
- Male
- Middle Aged
- Mineralocorticoid Receptor Antagonists
(therapeutic use)
- Prospective Studies
- Spironolactone
(therapeutic use)
- Time Factors
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