Abstract | BACKGROUND: MATERIALS AND METHODS: The possible prognostic factors were retrospectively analyzed in 85 patients with large HCC (> or = 10.0 cm) who all underwent a hepatectomy for HCC between 1988 and 2004. A survival analysis was made by classifying the tumors into four spreading patterns according to the number of tumors and the presence of macroscopic tumor thrombus. RESULTS: A positive hepatitis B antigen, the earlier period of hepatectomy, a non-curative hepatectomy, multiple tumors, and portal vein invasion were identified as independent predictors of a poor prognosis. The median survival term and 5-year survival rate of patients with a solitary large HCC without a macroscopic tumor thrombus was 9.8 years and 69.8%, respectively. The tumor spreading patterns according to the number of tumors and the presence of a macroscopic tumor thrombus were statistically associated with a non-curative hepatectomy (p < 0.001). There was a statistical difference among 33 patients with large HCC undergoing a non-curative hepatectomy based on the presence of a macroscopic portal vein invasion (p = 0.0089). CONCLUSION:
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Authors | Kazuaki Shimada, Yoshihiro Sakamoto, Minoru Esaki, Tomoo Kosuge |
Journal | Langenbeck's archives of surgery
(Langenbecks Arch Surg)
Vol. 393
Issue 4
Pg. 521-6
(Jul 2008)
ISSN: 1435-2451 [Electronic] Germany |
PMID | 18188585
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
(mortality, pathology, surgery)
- Disease Progression
- Disease-Free Survival
- Female
- Hepatectomy
(methods)
- Humans
- Japan
- Kaplan-Meier Estimate
- Liver Neoplasms
(mortality, pathology, surgery)
- Male
- Middle Aged
- Neoplasm Staging
- Neoplasm, Residual
(mortality, pathology, surgery)
- Neoplasms, Multiple Primary
(mortality, pathology, surgery)
- Neoplastic Cells, Circulating
(pathology)
- Prognosis
- Retrospective Studies
- Risk Factors
- Tumor Burden
- Young Adult
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