Abstract | OBJECTIVE: METHODS: Thirty-five patients with postsurgical neuropathic pain, postherpetic neuralgia, or diabetic neuropathy with allodynia or hyperalgesia were assigned to receive 3 topical creams (5% amitriptyline, 5% lidocaine, or placebo) in random sequence. The primary outcome measure was change in pain intensity (baseline vs. posttreatment average pain) using a 0 to 100 mm Visual Analog Scale. Secondary outcome measures included the McGill Pain Questionnaire, requirement for rescue medication, and patient satisfaction. Primary statistical comparisons were made with paired t tests or signed-rank tests. RESULTS: A reduction in pain intensity was observed with topical lidocaine (P<0.05). No significant change in pain intensity was found with topical amitriptyline or placebo. In pairwise comparison of treatments, topical lidocaine and placebo each reduced pain more than topical amitriptyline (P<0.05). DISCUSSION:
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Authors | Kok-Yuen Ho, Billy K Huh, William D White, Chun-Chang Yeh, Eric J Miller |
Journal | The Clinical journal of pain
(Clin J Pain)
Vol. 24
Issue 1
Pg. 51-5
(Jan 2008)
ISSN: 0749-8047 [Print] United States |
PMID | 18180637
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Anesthetics, Local
- Amitriptyline
- Lidocaine
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Topics |
- Administration, Topical
- Amitriptyline
(administration & dosage, adverse effects, therapeutic use)
- Analgesics, Non-Narcotic
(administration & dosage, adverse effects, therapeutic use)
- Anesthetics, Local
(administration & dosage, adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Lidocaine
(administration & dosage, adverse effects, therapeutic use)
- Male
- Middle Aged
- Pain
(drug therapy, etiology)
- Pain Measurement
- Peripheral Nervous System Diseases
(complications)
- Prospective Studies
- Sample Size
- Surveys and Questionnaires
- Treatment Outcome
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