Abstract | BACKGROUND: METHODS AND DESIGN: The Mupirocin Versus Polysporin Triple Study (MP3) is a multicenter, randomized, double-blinded controlled study comparing Polysporin Triple (P3) against the current standard of care. The aim of the study is to recruit 200 patients being treated with or starting on PD and randomize them to receive either mupirocin or P3 at the catheter exit site. Patients will be followed for 18 months or until death or transfer from PD to an alternate treatment modality. The primary outcome will be the time to first catheter-related infection. Catheter-related infections will be strictly defined using current guidelines and categorized into exit-site infections, infective peritonitis, or tunnel infections. The primary analysis will be an intention-to-treat analysis. DISCUSSION:
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Authors | Sarbjit V Jassal, Charmaine E Lok, MP3 Study Group |
Journal | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
(Perit Dial Int)
2008 Jan-Feb
Vol. 28
Issue 1
Pg. 67-72
ISSN: 0896-8608 [Print] United States |
PMID | 18178950
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Drug Combinations
- polysporin ointment
- Bacitracin
- Gramicidin
- Mupirocin
- Polymyxin B
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Topics |
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
- Bacitracin
(therapeutic use)
- Bacterial Infections
(etiology, prevention & control)
- Catheters, Indwelling
(adverse effects)
- Data Interpretation, Statistical
- Double-Blind Method
- Drug Combinations
- Gramicidin
(therapeutic use)
- Humans
- Mupirocin
(therapeutic use)
- Patient Selection
- Peritoneal Dialysis
(adverse effects)
- Peritonitis
(prevention & control)
- Polymyxin B
(therapeutic use)
- Sample Size
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