Abstract | OBJECTIVE: METHODS: Review of literature. RESULTS: There are no prospective, randomized works comparing the effects of anesthetics in the treatment of RSE. Recently, the use of propofol has increased in the treatment of RSE. Propofol terminates both clinical and electric seizures quickly, but the maintenance of burst-suppression EEG pattern requires repetitive titration of doses. Relapses of seizures have occurred in 19-33% of patients, especially when tapering of dose. The advantages of barbiturates are lower frequency of short-term treatment failures, breakthrough seizures and changes to a different anesthetic agent. On the other hand, prolonged recovery leads to prolonged duration of mechanical ventilation, intensive care and hospital stay. DISCUSSION:
|
Authors | Ilkka Parviainen, Reetta Kälviäinen, Esko Ruokonen |
Journal | Neurological research
(Neurol Res)
Vol. 29
Issue 7
Pg. 667-71
(Oct 2007)
ISSN: 0161-6412 [Print] England |
PMID | 18173905
(Publication Type: Journal Article, Review)
|
Chemical References |
- Anesthetics, Intravenous
- Anticonvulsants
- Barbiturates
- Midazolam
- Propofol
|
Topics |
- Anesthetics, Intravenous
(administration & dosage, adverse effects)
- Anticonvulsants
(administration & dosage, adverse effects)
- Barbiturates
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Humans
- Midazolam
(administration & dosage, adverse effects)
- Propofol
(administration & dosage, adverse effects)
- Respiratory Insufficiency
(chemically induced, physiopathology)
- Seizures
(drug therapy, physiopathology)
- Status Epilepticus
(drug therapy, physiopathology)
- Ventilator Weaning
|