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Methotrexate with citrovorum factor rescue for nonmetastatic gestational trophoblastic neoplasms.

Abstract
Fifteen patients with nonmetastatic gestational trophoblastic neoplasms were treated primarily with methotrexate and citrovorum factor. Complete and sustained remission was achieved in 14 of the 15 patients. Response to treatment was determined solely on the basis of serial serum human chorionic gonadotropin levels as measured by the beta subunit radioimmunoassay. All patients developed nonmetastatic gestational trophoblastic neoplasms following evacuation of a molar pregnancy. The known histologic diagnosis in all cases was hydatidiform mole. No significant toxicity was encountered despite careful monitoring of marrow, hepatic, renal, neurologic, and mucocutaneous parameters. Up to January 31, 1976, duration of remission ranged from 2 to 14 months.
AuthorsD P Goldstein, P R Goldstein, P Bottomley, R Osathanondh, A R Marean
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 48 Issue 3 Pg. 321-3 (Sep 1976) ISSN: 0029-7844 [Print] United States
PMID181702 (Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Leucovorin
  • Methotrexate
Topics
  • Adolescent
  • Adult
  • Clinical Trials as Topic
  • Drug Evaluation
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hydatidiform Mole (drug therapy)
  • Leucovorin (therapeutic use)
  • Methotrexate (adverse effects, therapeutic use)
  • Parity
  • Pregnancy
  • Remission, Spontaneous
  • Trophoblastic Neoplasms (drug therapy)
  • Uterine Neoplasms (drug therapy)

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