Abstract | BACKGROUND: OBJECTIVE: To compare clinicopathologic and MRI features of subjects with progressive aphasia and AD pathology to subjects with aphasia and FTLD-U pathology and subjects with typical AD. METHODS: We identified 5 subjects with aphasia and AD pathology and 5 with aphasia and FTLD-U pathology with an MRI from a total of 216 aphasia subjects. Ten subjects with typical AD clinical features and AD pathology were also identified. All subjects with AD pathology underwent pathologic reanalysis with TDP-43 immunohistochemistry. Voxel-based morphometry (VBM) was used to assess patterns of gray matter atrophy in the aphasia cases with AD pathology, aphasia cases with FTLD-U, and typical AD cases with AD pathology, compared with a normal control group. RESULTS: All aphasic subjects had fluent speech output. However, those with AD pathology had better processing speed than those with FTLD-U pathology. Immunohistochemistry with TDP-43 antibodies was negative. VBM revealed gray matter atrophy predominantly in the temporoparietal cortices, with notable sparing of the hippocampus in the aphasia with AD subjects. In comparison, the aphasic subjects with FTLD-U showed sparing of the parietal lobe. Typical AD subjects showed temporoparietal and hippocampal atrophy. CONCLUSIONS:
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Authors | K A Josephs, J L Whitwell, J R Duffy, W A Vanvoorst, E A Strand, W T Hu, B F Boeve, N R Graff-Radford, J E Parisi, D S Knopman, D W Dickson, C R Jack Jr, R C Petersen |
Journal | Neurology
(Neurology)
Vol. 70
Issue 1
Pg. 25-34
(Jan 01 2008)
ISSN: 1526-632X [Electronic] United States |
PMID | 18166704
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(metabolism, pathology)
- Aphasia
(metabolism, pathology)
- Brain Mapping
- Case-Control Studies
- Female
- Humans
- Inclusion Bodies
(pathology)
- Magnetic Resonance Imaging
(methods)
- Male
- Neuropsychological Tests
- Retrospective Studies
- Ubiquitin
(metabolism)
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