Abstract |
Wilson's disease is an inherited, autosomal recessive disorder of copper accumulation and toxicity. Lifelong chelation therapy is essential in all Wilson's disease patients. Intestinal absorption of some compounds is limited partly because they are preferentially transported in the secretory direction. Several ATP-binding cassette ( ABC) transporters are expressed in the apical membrane of the small intestine and secrete various drugs into the lumen. In this study, we investigated the characteristics of the intestinal efflux ABC transporters in LEC rats. We found that the expression of multidrug resistance-associated protein 2 (Mrp2) in the jejunum of Long-Evans Cinnamon (LEC) rats, an animal model for Wilson's disease, is decreased.
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Authors | Makoto Chiba, Shirou Itagaki, Masaki Kobayashi, Takeshi Hirano, Ken Iseki |
Journal | Drug metabolism and pharmacokinetics
(Drug Metab Pharmacokinet)
Vol. 22
Issue 6
Pg. 450-5
(Dec 2007)
ISSN: 1347-4367 [Print] England |
PMID | 18159133
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ATP-Binding Cassette Transporters
- Abcc2 protein, rat
- RNA, Messenger
- Sulfobromophthalein
- Mannitol
- Pravastatin
- Probenecid
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Topics |
- ATP-Binding Cassette Transporters
(antagonists & inhibitors, genetics, metabolism)
- Animals
- Disease Models, Animal
- Down-Regulation
- Hepatolenticular Degeneration
(metabolism)
- Jejunum
(drug effects, metabolism)
- Male
- Mannitol
(metabolism)
- Pravastatin
(metabolism)
- Probenecid
(pharmacology)
- RNA, Messenger
(analysis)
- Rats
- Rats, Inbred LEC
- Rats, Wistar
- Species Specificity
- Sulfobromophthalein
(pharmacology)
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