HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans cinnamon rats.

Abstract
Wilson's disease is an inherited, autosomal recessive disorder of copper accumulation and toxicity. Lifelong chelation therapy is essential in all Wilson's disease patients. Intestinal absorption of some compounds is limited partly because they are preferentially transported in the secretory direction. Several ATP-binding cassette (ABC) transporters are expressed in the apical membrane of the small intestine and secrete various drugs into the lumen. In this study, we investigated the characteristics of the intestinal efflux ABC transporters in LEC rats. We found that the expression of multidrug resistance-associated protein 2 (Mrp2) in the jejunum of Long-Evans Cinnamon (LEC) rats, an animal model for Wilson's disease, is decreased.
AuthorsMakoto Chiba, Shirou Itagaki, Masaki Kobayashi, Takeshi Hirano, Ken Iseki
JournalDrug metabolism and pharmacokinetics (Drug Metab Pharmacokinet) Vol. 22 Issue 6 Pg. 450-5 (Dec 2007) ISSN: 1347-4367 [Print] England
PMID18159133 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • ATP-Binding Cassette Transporters
  • Abcc2 protein, rat
  • RNA, Messenger
  • Sulfobromophthalein
  • Mannitol
  • Pravastatin
  • Probenecid
Topics
  • ATP-Binding Cassette Transporters (antagonists & inhibitors, genetics, metabolism)
  • Animals
  • Disease Models, Animal
  • Down-Regulation
  • Hepatolenticular Degeneration (metabolism)
  • Jejunum (drug effects, metabolism)
  • Male
  • Mannitol (metabolism)
  • Pravastatin (metabolism)
  • Probenecid (pharmacology)
  • RNA, Messenger (analysis)
  • Rats
  • Rats, Inbred LEC
  • Rats, Wistar
  • Species Specificity
  • Sulfobromophthalein (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: