[Diffused suberitrodermic psoriasis induced by infliximab].

Abstract

The case of a young male is described, affected by Crohn disease with reactive Spondylarthritis essay with Infliximab to the dose of 3 mg/kgs. After 15 days from the third infusion, the patient developed a first psoriasis eruption to the palm of the hands and the plant of the feet, for which was begun topical therapy with cortisone. After an initial improvement, the patient suffered a diffusion of the psoriasis eruption to the whole trunk and the limbs with a suberitrodermic aspect. The possible pathogenesis of this paradoxical effect of the anti-TNF is considered. Also being still partly the causes, is important the inhibition of the TNF-alpha with consequent expansion of the INF-alpha, in turn potential inductor of psoriasis.

• Authors: V Bruzzese
• Journal: Reumatismo (Reumatismo) 2007 Oct-Dec Vol. 59 Issue 4 Pg. 328-31 ISSN: 0048-7449 [Print] Italy
• Vernacular Title: Psoriasi suberitrodermica diffusa indotta da infliximab.
• PMID: 18157290 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Anti-Inflammatory Agents
• Antibodies, Monoclonal
• Immunosuppressive Agents
• Cyclosporine
• Infliximab

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Anti-Inflammatory Agents (adverse effects, immunology, therapeutic use)
• Antibodies, Monoclonal (adverse effects, immunology, therapeutic use)
• Crohn Disease (complications)
• Cyclosporine (therapeutic use)
• Drug Eruptions (etiology)
• Drug Therapy, Combination
• Humans
• Immunosuppressive Agents (therapeutic use)
• Infliximab
• Male
• Psoriasis (chemically induced, drug therapy)
• Skin (drug effects)
• Spondylarthritis (complications, drug therapy)
• Treatment Outcome