Ketoconazole hepatotoxicity in a patient treated for environmental illness and systemic candidiasis.

Abstract

Environmental illness, a hypothesized disease caused by exposure to substances such as combustion products, pesticides, food additives, and Candida albicans, is discussed. The case of a patient with environmental illness and systemic candidiasis for six weeks with ketoconazole, liver enzyme concentrations increased. One month after discontinuation of ketoconazole, the liver enzyme concentrations decreased; however, over the next five months, liver enzymes and bilirubin increased. The patient developed encephalopathy and eventually was transferred to a medical center for possible liver transplant. A review of the literature pertaining to ketoconazole hepatotoxicity is also presented.

• Authors: C S Brusko, J T Marten
• Journal: DICP : the annals of pharmacotherapy (DICP) Vol. 25 Issue 12 Pg. 1321-5 (Dec 1991) ISSN: 1042-9611 [Print] United States
• PMID: 1815425 (Publication Type: Case Reports, Comparative Study, Journal Article, Review)

Chemical References

• Environmental Pollutants
• Ketoconazole

Topics

• Adult
• Candidiasis (drug therapy)
• Chemical and Drug Induced Liver Injury (enzymology, etiology)
• Environmental Exposure (adverse effects)
• Environmental Pollutants (poisoning)
• Female
• Humans
• Jaundice (chemically induced, enzymology)
• Ketoconazole (adverse effects, therapeutic use)
• Liver Diseases (enzymology)
• Male
• Middle Aged