[Inhibition of tumor growth in rat liver induced by tumor-specific transfer factor].

Abstract

A transfer factor (TF) specific to antigens of Geren's carcinoma in rat was developed using an original model of intraorganic growth. Intravenous injection (1pg/g body) inhibited primary tumor node growth in the liver by 78% and blocked dissemination to peritoneal viscera. Its effect was due to an immunospecific component promoting antitumor immunological response. The latter presented as generation of cytotoxic effector cells, vascular disorders in tumor parenchyma thus blocking tumor cell proliferation. Possible applications of tumor-specific TF for biotherapy of cancer patients are discussed.

• Authors: Iu A Grinevich, F V Ful'chakov, E S Shumilina, L I Bodro, A D Len
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 53 Issue 5 Pg. 566-71 ( 2007) ISSN: 0507-3758 [Print] Russia (Federation)
• PMID: 18154122 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Histocompatibility Antigens
• tumor-associated transplantation antigen

Topics

• Animals
• Antigens, Neoplasm (administration & dosage, immunology, pharmacology)
• Carcinoma (immunology, prevention & control)
• Histocompatibility Antigens (administration & dosage, immunology, pharmacology)
• Injections, Intravenous
• Liver Neoplasms, Experimental (immunology, pathology, prevention & control)
• Rats
• Splenic Neoplasms (immunology)