Abstract |
A study was undertaken to learn whether the young Mg-deficient mammal can respond to major stress with increased levels of plasma corticosterone. Plasma corticosterone was determined in 48 weanling rats with dietary Mg deficiency and in 48 Mg-sufficient controls fed a Mg-supplemented diet, studying 12 animals at a time on experimental day 14. Each animal was studied once, either in an unstressed state or after the stress of audiogenic or strychnine seizures. Plasma corticosterone was determined using a radioimmunoassay; Mg was analyzed by atomic absorption spectrophotometry. On experimental day 14, unstressed Mg-deficient rats were tremulous, hyperirritable and showed slightly increased plasma corticosterone levels that exceeded controls levels. After strychnine shock, the mean plasma corticosterone levels of Mg-sufficient and Mg-deficient rats were both significantly increased over resting levels, and were not statistically different. Moreover, the spontaneous mortality rate that occurred during the experimental period in all Mg-sufficient rats was 0 compared to 27% among all Mg-deficient animals (p less than 0.0001). It was concluded that young rats deficient in Mg for 2 weeks could respond to major stress with levels of plasma corticosterone that were not significantly different from values of equally stressed Mg-sufficient controls. The deficient animals suffered a higher mortality, providing support for the concept that Mg deficiency increases stress-induced mortality in animals.
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Authors | J L Caddell, J D Dunn |
Journal | Magnesium and trace elements
(Magnes Trace Elem)
1991-1992
Vol. 10
Issue 1
Pg. 40-6
ISSN: 1015-3845 [Print] Switzerland |
PMID | 1814323
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Animals
- Bone and Bones
(chemistry)
- Corticosterone
(blood)
- Magnesium
(blood)
- Magnesium Deficiency
(blood)
- Male
- Rats
- Rats, Inbred Strains
- Stress, Physiological
(blood)
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