Abstract |
The effects of 9-amino-1,2,3,4-tetrahydroacridine ( tacrine), an active acetylcholinesterase inhibitor, on cycloheximide- and basal forebrain (BF) lesion-induced memory deficit in the water maze and passive avoidance task were investigated. While cycloheximide (1.5 mg/kg, s.c.) produced amnesia in the passive avoidance task, chronic administration of tacrine (1, 3 and 10 mg/kg, once a day for 1 week) improved the amnesia. BF lesion produced amnesia in both the water maze and passive avoidance tasks. Chronic tacrine (0.1-3 mg/kg, passive avoidance task, or 0.3 mg/kg, water maze task, once a day for 1 week) improved BF lesion-induced amnesia in the passive avoidance and water maze tasks. These results suggest that tacrine may be useful for senile dementia.
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Authors | T Nabeshima, E Maruyama, A Katoh, T Kameyama |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 57
Issue 3
Pg. 311-9
(Nov 1991)
ISSN: 0021-5198 [Print] Japan |
PMID | 1813659
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Tacrine
- Cycloheximide
- Choline O-Acetyltransferase
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Topics |
- Administration, Oral
- Amnesia
(chemically induced, drug therapy, etiology)
- Animals
- Aphasia
(etiology)
- Ataxia
(etiology)
- Avoidance Learning
(drug effects)
- Behavior, Animal
(drug effects)
- Brain Diseases
(chemically induced, complications, enzymology)
- Choline O-Acetyltransferase
(metabolism)
- Cycloheximide
- Dose-Response Relationship, Drug
- Male
- Memory Disorders
(chemically induced, drug therapy, etiology)
- Prosencephalon
(drug effects, physiology)
- Rats
- Rats, Inbred Strains
- Tacrine
(pharmacology)
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