The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats.

Abstract

The effects of 9-amino-1,2,3,4-tetrahydroacridine (tacrine), an active acetylcholinesterase inhibitor, on cycloheximide- and basal forebrain (BF) lesion-induced memory deficit in the water maze and passive avoidance task were investigated. While cycloheximide (1.5 mg/kg, s.c.) produced amnesia in the passive avoidance task, chronic administration of tacrine (1, 3 and 10 mg/kg, once a day for 1 week) improved the amnesia. BF lesion produced amnesia in both the water maze and passive avoidance tasks. Chronic tacrine (0.1-3 mg/kg, passive avoidance task, or 0.3 mg/kg, water maze task, once a day for 1 week) improved BF lesion-induced amnesia in the passive avoidance and water maze tasks. These results suggest that tacrine may be useful for senile dementia.

• Authors: T Nabeshima, E Maruyama, A Katoh, T Kameyama
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 57 Issue 3 Pg. 311-9 (Nov 1991) ISSN: 0021-5198 [Print] Japan
• PMID: 1813659 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Tacrine
• Cycloheximide
• Choline O-Acetyltransferase

Topics

• Administration, Oral
• Amnesia (chemically induced, drug therapy, etiology)
• Animals
• Aphasia (etiology)
• Ataxia (etiology)
• Avoidance Learning (drug effects)
• Behavior, Animal (drug effects)
• Brain Diseases (chemically induced, complications, enzymology)
• Choline O-Acetyltransferase (metabolism)
• Cycloheximide
• Dose-Response Relationship, Drug
• Male
• Memory Disorders (chemically induced, drug therapy, etiology)
• Prosencephalon (drug effects, physiology)
• Rats
• Rats, Inbred Strains
• Tacrine (pharmacology)