Antibody response against autologous and heterologous isolates of Borrelia burgdorferi in four patients with Lyme neuroborreliosis.

Abstract

Serum and cerebrospinal fluid (CSF) samples from four patients with Lyme neuroborreliosis were analyzed for IgM and IgG antibodies by an indirect enzyme immunoassay with the four patients' own CSF isolate of Borrelia burgdorferi and two tick isolates, strains STG152 and B31, as antigens. No major differences in the antibody response were found comparing autologous and heterologous strains as sonicate antigens, although a tendency towards a stronger response to the autologous isolates was noted in samples from two patients.

• Authors: M Karlsson
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 10 Issue 9 Pg. 742-5 (Sep 1991) ISSN: 0934-9723 [Print] Germany
• PMID: 1810726 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Bacterial
• Immunoglobulin G
• Immunoglobulin M

Topics

• Antibodies, Bacterial (cerebrospinal fluid)
• Borrelia burgdorferi Group (immunology)
• Humans
• Immunoenzyme Techniques
• Immunoglobulin G (blood, cerebrospinal fluid)
• Immunoglobulin M (blood, cerebrospinal fluid)
• Lyme Disease (cerebrospinal fluid, immunology)
• Nervous System Diseases (cerebrospinal fluid, immunology)