[The correction of disorders in the cytoenzymatic status of the immunocytes in Shigella infection by using taktivin].

Abstract

Cytoenzymatic and morphological methods were used to reveal local and general immunity disorders in patients with lingering and chronic dysentery. In this connection the therapeutic effect of the immunomodulator T-activin was estimated. 51 patients with the above forms of dysentery were examined. The patients were distributed into basic groups given T-activin and control groups not on the drug. The function of immune cells was evaluated by the enzymic status--the ratio of the activity of the following enzymes: succinate and glycerophosphate dehydrogenases, NADP and acid phosphatase. One of the causes of chronic dysentery was functional deficiency of lymphoid and phagocytizing cells of the colonic mucosa, supported by the data on their enzymic status. Analogous deficiency was discovered in peripheral blood leukocytes. T-activin successfully corrects the revealed immune disorders, stimulates metabolic processes in the cells and reduces inflammation and ameliorates the repair of the intestinal mucosa as well.

• Authors: N Guliamov, M I Kriuchkov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 63 Issue 11 Pg. 27-30 ( 1991) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: O korrektsii narusheniĭ tsitofermentnogo statusa immunotsitov pri shigelleznoĭ infektsii s pomoshch'iu taktivina.
• PMID: 1810056 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Peptides
• Thymus Extracts
• T-activin
• Oxidoreductases

Topics

• Adjuvants, Immunologic (therapeutic use)
• Biopsy
• Drug Evaluation
• Dysentery, Bacillary (drug therapy, enzymology, immunology, pathology)
• Histocytochemistry
• Humans
• Intestinal Mucosa (drug effects, enzymology, immunology, ultrastructure)
• Intestine, Large (drug effects, enzymology, immunology, ultrastructure)
• Lymphocytes (drug effects, enzymology, immunology, ultrastructure)
• Microscopy, Electron
• Oxidoreductases (drug effects, metabolism)
• Peptides (therapeutic use)
• Thymus Extracts (therapeutic use)