Abstract | BACKGROUND: METHODS: RESULTS: Although OPRT levels were high in well-differentiated and localized carcinomas, they were not correlated with other clinicopathological variables or with the pathological stage of gastric carcinoma. Levels of OPRT were significantly higher in gastric carcinoma tissue than in normal gastric mucosa. OPRT levels were not correlated with levels of either thymidylate synthase or dihydropyrimidine dehydrogenase. In samples of gastric carcinoma tissues and normal gastric mucosa tissues obtained simultaneously from 24 patients, no correlation was found between OPRT levels in gastric carcinoma and levels in normal gastric mucosa. CONCLUSION: These results suggest that the OPRT level is significantly higher in gastric carcinoma tissue than in normal gastric mucosa and that the OPRT level in gastric carcinoma is a novel variable that is independent of the levels of other previously known enzymes related to 5-fluorouracil (FU) metabolism.
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Authors | Yoichi Sakurai, Shingo Kamoshida, Shinpei Furuta, Risaburo Sunagawa, Kazuki Inaba, Jun Isogaki, Yoshiyuki Komori, Ichiro Uyama, Yutaka Tsutsumi |
Journal | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
(Gastric Cancer)
Vol. 10
Issue 4
Pg. 234-40
( 2007)
ISSN: 1436-3291 [Print] Japan |
PMID | 18095079
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Dihydrouracil Dehydrogenase (NADP)
- Thymidylate Synthase
- Orotate Phosphoribosyltransferase
- Fluorouracil
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Topics |
- Adenocarcinoma
(drug therapy, enzymology, pathology)
- Aged
- Antimetabolites, Antineoplastic
(pharmacokinetics)
- Dihydrouracil Dehydrogenase (NADP)
(metabolism)
- Female
- Fluorouracil
(pharmacokinetics)
- Gastric Mucosa
(enzymology, pathology)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Orotate Phosphoribosyltransferase
(metabolism)
- Stomach Neoplasms
(drug therapy, enzymology, pathology)
- Thymidylate Synthase
(metabolism)
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