Abstract | CONTEXT AND OBJECTIVE: DESIGN AND SETTING: This was a randomized, double-blind, placebo-controlled clinical trial carried out in the Mastology Sector, Department of Gynecology, Universidade Federal de São Paulo. METHODS: We studied 33 women with fibroadenomas. Ten were placed in group 1 and took an oral contraceptive consisting of levonorgestrel and ethinyl estradiol together with placebo material in the same capsule, for four consecutive cycles with a seven-day interval between them. The other 23 patients constituted group 2 and took the oral contraceptive as above together with estriol in the same capsule, in the same way as done by the group 1 patients. We took ultrasound measurements of their tumors (in three dimensions) before and after the intake of medication. At the end of the study, all the patients had their tumors removed by surgery. RESULTS: We observed decreased fibroadenoma width among the users of oral contraceptives with placebo, and this decrease was statistically significant. In the other group, we did not observe any changes (in width, length or height). CONCLUSION:
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Authors | Rodrigo Augusto Fernandes Estevão, Afonso Celso Pinto Nazário, Edmund Chada Baracat |
Journal | Sao Paulo medical journal = Revista paulista de medicina
(Sao Paulo Med J)
Vol. 125
Issue 5
Pg. 275-80
(Sep 06 2007)
ISSN: 1516-3180 [Print] Brazil |
PMID | 18094894
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Contraceptives, Oral, Combined
- Progesterone
- Ethinyl Estradiol-Norgestrel Combination
- Estriol
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Topics |
- Adult
- Biopsy
- Breast Neoplasms
(diagnostic imaging, drug therapy, pathology)
- Contraceptives, Oral, Combined
(antagonists & inhibitors, therapeutic use)
- Double-Blind Method
- Estriol
(therapeutic use)
- Ethinyl Estradiol-Norgestrel Combination
(antagonists & inhibitors, therapeutic use)
- Female
- Fibroadenoma
(diagnostic imaging, drug therapy, pathology)
- Humans
- Progesterone
(blood)
- Statistics, Nonparametric
- Ultrasonography
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