Abstract | BACKGROUND: METHODS: Male Wistar Kyoto (WKY) rats or spontaneously hypertensive rats (SHRs, 14 weeks old) were divided into the following four groups; those on a control diet, 0.005% HHQ diet, 0.5% CQA diet, and HHQ plus CQA diet. The rats were fed the above diets for 8 weeks, and the tail arterial blood pressure was monitored in conscious rats at 2-week intervals. Urinary nitric oxide (NO) metabolites and hydrogen peroxide (H(2)O(2)) excretion were measured 8 weeks after the start of the experiment. Endothelium-dependent and -independent vasorelaxant responses and immunohistochemical staining for nitrotyrosine were examined in aortas. RESULTS: HHQ inhibited the CQA-induced improvement in hypertension, urinary NO metabolites or H(2)O(2) excretion, endothelial dysfunction, and nitrotyrosine deposits in aortas in SHR. However, the administration of HHQ alone had little effect on either strain. CONCLUSIONS: Based on the content ratio of HHQ and chlorogenic acids in coffee, HHQ interfered with the CQA-induced improvement in blood pressure and endothelial function in SHR. The results explain, at least in part, the conflicting action of coffee drinking on hypertension and vascular reactivity.
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Authors | Atsushi Suzuki, Akihiko Fujii, Hiroko Jokura, Ichiro Tokimitsu, Tadashi Hase, Ikuo Saito |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 21
Issue 1
Pg. 23-7
(Jan 2008)
ISSN: 0895-7061 [Print] United States |
PMID | 18091740
(Publication Type: Journal Article)
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Chemical References |
- Antihypertensive Agents
- Hydroquinones
- Vasodilator Agents
- caffeoylquinic acid
- Quinic Acid
- Nitroprusside
- hydroxyhydroquinone
- Chlorogenic Acid
- Nitric Oxide
- 3-nitrotyrosine
- Tyrosine
- Hydrogen Peroxide
- Acetylcholine
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Topics |
- Acetylcholine
(pharmacology)
- Animals
- Antihypertensive Agents
(blood, pharmacology, therapeutic use)
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Chlorogenic Acid
(blood, pharmacology, therapeutic use)
- Disease Models, Animal
- Endothelium, Vascular
(drug effects, metabolism, physiopathology)
- Heart Rate
(drug effects)
- Hydrogen Peroxide
(urine)
- Hydroquinones
(pharmacology)
- Hypertension
(drug therapy, metabolism, physiopathology)
- Immunohistochemistry
- Male
- Nitric Oxide
(urine)
- Nitroprusside
(pharmacology)
- Quinic Acid
(analogs & derivatives, blood, pharmacology, therapeutic use)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Time Factors
- Tyrosine
(analogs & derivatives, metabolism)
- Vasodilation
(drug effects)
- Vasodilator Agents
(pharmacology)
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