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[The effect of plasmapheresis on the clinical and laboratory parameters of patients with idiopathic thrombocytopenic purpura].

Abstract
It is shown that plasmapheresis (PA) as an adjuvant modality in combined treatment of idiopathic purpura resistant to glucocorticosteroids helps to partially overcome resistance and induces a positive trend in the clinical and hematological indices. Pretreatment number of glucocorticoid receptors in lymphocytes and the androgenic cortisol level in patients resistant to glucocorticosteroids were significantly lowered and rose after a course of therapeutic plasmapheresis. A PA positive effect is attributed to elimination from the vascular bed of circulating immune complexes, mid-mass molecules as well as raising the blockade of lymphocytic membranes.
AuthorsA A Kerimov, L G Kalinichenko, T N Guseĭnov, L I Babaeva
JournalKlinicheskaia meditsina (Klin Med (Mosk)) Vol. 69 Issue 11 Pg. 67-9 (Nov 1991) ISSN: 0023-2149 [Print] Russia (Federation)
Vernacular TitleVliianie plazmafereza na kliniko-laboratornye pokazateli u bol'nykh idiopaticheskoĭ trombotsitopenicheskoĭ purpuroĭ.
PMID1808413 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Receptors, Glucocorticoid
Topics
  • Adolescent
  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Plasmapheresis
  • Purpura, Thrombocytopenic, Idiopathic (physiopathology, therapy)
  • Receptors, Glucocorticoid

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