Endoscopic patterns and histopathological features after eradication therapy in Helicobacter pylori-associated nodular gastritis.

Abstract	The endoscopic finding of nodular gastritis (NG) is highly associated with presence of Helicobacter pylori infection. How the endoscopic patterns and histopathology of NG change after eradication of H. pylori is unclear. Twenty-one adults (3 men and 18 women) with H. pylori-associated NG found on endoscopy were enrolled for this study. The histological findings included gastritis activity, bacterial colonization, and lymphoid follicles. Repeat endoscopy for the endoscopic as well as histopathological features of gastric biopsy specimens was performed 2 months later after eradication treatment. H. pylori was successfully eradicated in 19 patients. Endoscopic NG disappeared in 12, improved in 5, and was unchanged in 4. After treatment, there was significant improvement in scores for gastritis activity [P < 0.001, 95% confidence interval (CI) 1.31-1.91], bacterial colonization (P < 0.001, 95% CI 0.71-1.14) and follicular gastritis (P = 0.047, 95% CI 0.04-0.52), primarily among patients whose endoscopic pattern resolved completely. The disappearance of nodularity on endoscopy was accompanied by a decrease in follicular gastritis score.
Authors	Ming-Jen Chen, Shou-Chuan Shih, Tsang-En Wang, Yu-Jan Chan, Chih-Jen Chen, Wen-Hsiung Chang
Journal	Digestive diseases and sciences (Dig Dis Sci) Vol. 53 Issue 7 Pg. 1893-7 (Jul 2008) ISSN: 0163-2116 [Print] United States
PMID	18080192 (Publication Type: Journal Article)
Chemical References	2-Pyridinylmethylsulfinylbenzimidazoles Alkylating Agents Anti-Bacterial Agents Anti-Ulcer Agents Tinidazole Lansoprazole Amoxicillin
Topics	2-Pyridinylmethylsulfinylbenzimidazoles (administration & dosage) Adult Alkylating Agents (administration & dosage) Amoxicillin (administration & dosage) Anti-Bacterial Agents (administration & dosage) Anti-Ulcer Agents (administration & dosage) Biopsy Drug Therapy, Combination Female Gastritis (drug therapy, microbiology, pathology) Gastroscopy Helicobacter Infections (drug therapy, pathology) Helicobacter pylori Humans Lansoprazole Male Middle Aged Prospective Studies Tinidazole (administration & dosage) Treatment Outcome

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