N epsilon-(carboxymethyl)lysine during the early development of hypertension.

Abstract

Advanced glycation end products (AGEs) are associated with hypertension. Whether N(epsilon)-(carboxymethyl)lysine (CML) contributes to the development of hypertension in young spontaneously hypertensive rats (SHR) remains to be established compared to WKY. We determined blood pressure, renal function, marker for oxidative stress (OS), and CML in young WKY rats and SHR. We found blood pressure was increased in SHR with no difference in renal function and OS compared to WKY. CML was elevated in plasma (2.3 +/- 0.3 vs. 1.3 +/- 0.2 micromol/L) and kidney (1.0 +/- 0.1 vs. 0.5 +/- 0.1 micromol/L) compared to WKY. Early CML accumulation may contribute to the development of hypertension potentially by inducing early renal inflammation independent of glomerular dysfunction or oxidative stress.

• Authors: Marcus Baumann, Coen Stehouwer, Jean Scheijen, Uwe Heemann, Harry Struijker Boudier, Casper Schalkwijk
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1126 Pg. 201-4 (Apr 2008) ISSN: 0077-8923 [Print] United States
• PMID: 18079484 (Publication Type: Journal Article)

Chemical References

• Glycation End Products, Advanced
• N(6)-carboxymethyllysine
• Creatinine
• Lysine

Topics

• Albuminuria
• Animals
• Blood Pressure
• Creatinine (metabolism)
• Glycation End Products, Advanced (metabolism)
• Heart Rate
• Humans
• Hypertension (physiopathology)
• Lysine (analogs & derivatives, metabolism)
• Oxidative Stress
• Rats
• Rats, Inbred SHR
• Rats, Inbred WKY