Abstract | BACKGROUND: METHODS: To further assess the role of this gene in WS, we genotyped the VNTR and 7 single nucleotide polymorphisms (SNPs) encompassing the DAT1 gene in a sample of 250 alcohol-dependent subjects (175 men and 75 women), of whom 24% exhibited WSs, taking into account the severity of alcohol dependence. RESULTS: The VNTR is associated with an increased risk of WSs (odd ratio = 3.5; p = 0.019), even when controlling for confounding factors (p = 0.031). As 2 SNPs, in roughly the same location of the gene (namely rs27072 and rs27048), are also associated with WSs, it is possible that the initial association of the VNTR polymorphism was tagging a specific haplotype of this gene. Indeed, in our sample of alcohol-dependent patients, 2 haplotypes were associated with a significantly different risk of WSs. CONCLUSIONS: The present study adds evidence for a significant role of the 3' part of the DAT1 gene in WS of alcohol-dependent patients, not only because it is in accordance with previous work, but also because of larger statistical power (as relying on a sample over sampled with the studied phenotype), as it gives a more precise analysis of different SNPs within the DAT1 gene, and as it confirms the association when major potentially confounding factors are taken into account in a logistical regression analysis.
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Authors | Yann Le Strat, Nicolas Ramoz, Paul Pickering, Virginie Burger, Claudette Boni, Henri-Jean Aubin, Jean Adès, Philippe Batel, Philip Gorwood |
Journal | Alcoholism, clinical and experimental research
(Alcohol Clin Exp Res)
Vol. 32
Issue 1
Pg. 27-35
(Jan 2008)
ISSN: 1530-0277 [Electronic] England |
PMID | 18070248
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dopamine Plasma Membrane Transport Proteins
- SLC6A3 protein, human
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Topics |
- Adult
- Age of Onset
- Alcohol Withdrawal Delirium
(complications)
- Alcohol Withdrawal Seizures
(complications, ethnology, genetics)
- Dopamine Plasma Membrane Transport Proteins
(genetics)
- Female
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Minisatellite Repeats
- Polymorphism, Single Nucleotide
- Sex Factors
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