[Rapid viral response during treatment of chronic hepatitis B with pegylated interferon alfa-2a in children--preliminary report].

Abstract

The aim of the study was to assess the viral response after 4 weeks of treatment with pegylated interferon alfa-2a chronic hepatitis B. Investigations were performed in 13 children in the age 11-17 years, with CHB, treated with PegIFN alfa-2a in the dose 100mcg/m2/week. After 4 weeks treatment statistically significant decrease of HBV viral load was observed. HBV DNA dissapearance was observed in 6/13 children with lower baseline ALT activity and lower HBV viral load before treatment. HBV DNA dissapearance was revealed in naïve children with anti-HBe serum presence. During treatment no adverse events following dosis modifications were observed. Our preliminary observations of early HBV viral load supression seem to reveal that peginterferon alfa-2a may be benefit therapeutic option for children with CHB.

• Authors: Małgorzata Pawłowska, Waldemar Halota
• Journal: Przeglad epidemiologiczny (Przegl Epidemiol) Vol. 61 Issue 3 Pg. 427-31 ( 2007) ISSN: 0033-2100 [Print] Poland
• Vernacular Title: Szybka odpowiedź wirusologiczna w przebiegu leczenia pegylowanym interferonem alfa-2a przewlekłego zapalenia watroby typu B u dzieci--doniesienie wstepne.
• PMID: 18069377 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Antiviral Agents
• Biomarkers
• DNA, Viral
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins
• Polyethylene Glycols
• peginterferon alfa-2a

Topics

• Adolescent
• Antibodies, Viral
• Antiviral Agents (administration & dosage)
• Biomarkers (blood)
• Child
• DNA, Viral (blood)
• Dose-Response Relationship, Drug
• Female
• Hepatitis B virus (immunology)
• Hepatitis B, Chronic (drug therapy, virology)
• Humans
• Interferon alpha-2
• Interferon-alpha (administration & dosage)
• Male
• Poland
• Polyethylene Glycols (administration & dosage)
• Recombinant Proteins
• Viral Load