Revaccination does not improve an observed deficit in antibody responses in Pakistani adults born of a lower birth weight.

Abstract

We have previously shown that the generation of antibodies to a polysaccharide vaccine (Typhim Vi) is compromised in Pakistani adults born of a lower birth weight. To assess whether this represents a true B-cell-dependent deficit, we revaccinated subjects with a second dose of the same vaccine and with a polysaccharide-protein conjugate vaccine to a different polysaccharide antigen (conjugated Haemophilus influenzae type b (Hib) vaccine). Anti-Vi IgG levels remained positively correlated with birth weight (p=0.0284) but no associations were observed between anti-Hib IgG levels and size at birth. These findings indicate that small size at birth results in a poor antibody response to vaccination with a polysaccharide antigen vaccine in adulthood, even following a second dose of the vaccine. No such association was observed in response to a polysaccharide-protein conjugate vaccine indicating an early-life programming effect on the generation of antibodies during a B-cell-dependent immune response.

• Authors: Sophie E Moore, Fehmida Jalil, Shousun Chen Szu, Mirjana Hahn-Zoric, Andrew M Prentice, Lars A Hanson
• Journal: Vaccine (Vaccine) Vol. 26 Issue 2 Pg. 158-65 (Jan 10 2008) ISSN: 0264-410X [Print] Netherlands
• PMID: 18068877 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Haemophilus Vaccines
• Immunoglobulin G
• Polysaccharides, Bacterial
• Typhoid-Paratyphoid Vaccines
• Vaccines, Conjugate
• Vi polysaccharide vaccine, typhoid

Topics

• Adult
• Antibodies, Bacterial (blood)
• Female
• Haemophilus Vaccines (immunology)
• Humans
• Immunization, Secondary
• Immunoglobulin G (blood)
• Infant, Low Birth Weight (immunology)
• Infant, Newborn
• Male
• Pakistan
• Polysaccharides, Bacterial (immunology)
• Typhoid-Paratyphoid Vaccines (immunology)
• Vaccines, Conjugate (immunology)