Abstract | OBJECTIVES: METHODS: Bladder inflammation was induced in rats by intravesicular inoculation of protamine sulfate and lipopolysaccharide. Groups of rats were randomly assigned to the treated or control groups, which received either the treatment agents or saline 24 hours after induction. The animals were killed 5 days after inoculation, and the bladders harvested for histologic examination of inflammation by a blinded observer. Four parameters of inflammation were measured using a 6-point scale. In another experiment, urinary frequency was measured 4 days after inoculation. RESULTS: The most potent treatment agent was 3% N-sulphonato-N, O-carboxymethylchitosan plus 5-ASA, with a mean reduction in inflammation, as measured by histologic examination, of up to 75%. This level of reduction was significantly greater than that seen by treatment with the commercially available product Cystistat. In a separate experiment, 3% N-sulphonato-N, O-carboxymethylchitosan plus 5-ASA ameliorated the increase in urinary frequency seen in induced, untreated animals. CONCLUSIONS:
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Authors | Julie L Jordan, Susan Henderson, Clive M Elson, Juan Zhou, Agis Kydonieus, John Downie, Timothy D G Lee |
Journal | Urology
(Urology)
Vol. 70
Issue 5
Pg. 1014-8
(Nov 2007)
ISSN: 1527-9995 [Electronic] United States |
PMID | 18068477
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- N-sulfonato-N,O-carboxymethylchitosan
- Chitin
- Mesalamine
- Chitosan
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Chitin
(analogs & derivatives, therapeutic use)
- Chitosan
(analogs & derivatives)
- Cystitis
(drug therapy)
- Female
- Mesalamine
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
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