Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats.

Abstract

RATIONALE:

Pyrilamine, a selective histamine H(1) antagonist, impaired spatial memory, and decreased hippocampal theta activity during a radial maze task.

OBJECTIVE:

We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the decrease in hippocampal theta activity in rats.

MATERIALS AND METHODS:

Drug effects were measured using an eight-arm radial maze with four arms baited. Hippocampal theta rhythm during the radial maze task was also recorded with a polygraph system using a telemetric technique.

RESULTS:

Intraperitoneal injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and a decrease in the amplitude and power of hippocampal theta waves. The working memory deficit and the decrease in hippocampal theta power were antagonized by intrahippocampal injection of D: -cycloserine (1 microg/side), spermidine (10 microg/side), spermine (10 microg/side), aniracetam (1 microg/side), and 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) (1 microg/side), but not concanavalin A.

CONCLUSION:

These results clearly indicate that H(1) antagonist-induced working memory deficit, and the decrease in hippocampal theta activity was closely associated with hippocampal glutamatergic neurotransmission mediated by N-methyl-D: -aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.

• Authors: Takayoshi Masuoka, Shunsuke Saito, Chiaki Kamei
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 197 Issue 1 Pg. 107-14 (Mar 2008) ISSN: 0033-3158 [Print] Germany
• PMID: 18066536 (Publication Type: Journal Article)

Chemical References

• Dioxoles
• Gluk2 kainate receptor
• Histamine H1 Antagonists
• Piperidines
• Pyrrolidinones
• Receptors, AMPA
• Receptors, Histamine H1
• Receptors, Kainic Acid
• Receptors, N-Methyl-D-Aspartate
• Concanavalin A
• Spermine
• 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine
• aniracetam
• Cycloserine
• Pyrilamine
• Spermidine

Topics

• Animals
• Concanavalin A (pharmacology)
• Cycloserine (pharmacology)
• Dioxoles (pharmacology)
• Dose-Response Relationship, Drug
• Electroencephalography (drug effects)
• Fourier Analysis
• Hippocampus (drug effects)
• Histamine H1 Antagonists (pharmacology)
• Injections
• Male
• Maze Learning (drug effects)
• Mental Recall (drug effects)
• Orientation (drug effects)
• Piperidines (pharmacology)
• Pyrilamine (antagonists & inhibitors, pharmacology)
• Pyrrolidinones (pharmacology)
• Rats
• Rats, Wistar
• Receptors, AMPA (drug effects)
• Receptors, Histamine H1 (drug effects)
• Receptors, Kainic Acid (drug effects)
• Receptors, N-Methyl-D-Aspartate (drug effects)
• Signal Processing, Computer-Assisted
• Spermidine (pharmacology)
• Spermine (pharmacology)
• Theta Rhythm