New 1-indanone thiosemicarbazone derivatives active against BVDV.

Abstract

Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI=80.29) than that of ribavirin (SI=11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus.

• Authors: Liliana M Finkielsztein, Eliana F Castro, Lucas E Fabián, Graciela Y Moltrasio, Rodolfo H Campos, Lucía V Cavallaro, Albertina G Moglioni
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 43 Issue 8 Pg. 1767-73 (Aug 2008) ISSN: 0223-5234 [Print] France
• PMID: 18063227 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 5,6-dimethoxy-1-indanone thiosemicarbazone
• Antiviral Agents
• Indans
• Thiosemicarbazones
• indacrinone

Topics

• Animals
• Antiviral Agents (chemical synthesis, chemistry, pharmacology)
• Cattle
• Cell Line
• Diarrhea Viruses, Bovine Viral (drug effects)
• Indans (chemical synthesis, chemistry, pharmacology)
• Molecular Structure
• Structure-Activity Relationship
• Thiosemicarbazones (chemical synthesis, chemistry, pharmacology)