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Experimental study on transarterial administration of GRGDSP combined with transarterial chemoembolization in rats with hepatic carcinoma.

AbstractPURPOSE:
To evaluate the effects of transarterial administration of an integrin antagonist, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro), combined with transarterial chemoembolization (TACE) to treat hepatic carcinoma in rats.
METHODS:
Walker-256 tumor was implanted beneath the liver capsule in 26 Wistar rats. Animal subjects were assigned to groups based on which treatment was injected into the hepatic artery: group A, GRGDSP + TACE; group B, TACE alone; and group C, normal saline. Magnetic resonance imaging (MRI), tumor pathology, and immunohistochemistry were performed to assess each treatment.
RESULTS:
The ratios of the post-treatment to pretreatment tumor volumes (V2/V1) in groups A, B, and C were 4.42 +/- 0.48, 6.98 +/- 1.09, and 13.00 +/- 1.68, respectively. The metastatic potential of the tumors was assessed by tumor cell nest counts, which were 5.00 +/- 1.25, 6.63 +/- 1.60, and 7.22 +/- 1.92 in groups A, B, and C, respectively. Microvessel density (MVD) was quantified by measuring von Willebrand factor density values, which were 0.18 +/- 0.02, 0.22 +/- 0.02, and 0.23 +/- 0.02 in groups A, B, and C, respectively.
CONCLUSIONS:
Transarterial infusion of GRGDSP combined with TACE noticeably inhibited the growth of hepatic carcinoma and intrahepatic metastases in rats.
AuthorsJun Qian, Jun Yin, Huimin Liang, Yong Wang, Gansheng Feng
JournalCardiovascular and interventional radiology (Cardiovasc Intervent Radiol) 2008 Mar-Apr Vol. 31 Issue 2 Pg. 377-82 ISSN: 1432-086X [Electronic] United States
PMID18058171 (Publication Type: Journal Article)
Chemical References
  • Oligopeptides
  • glycyl-arginyl-glycyl-aspartyl-seryl-proline
Topics
  • Animals
  • Chemoembolization, Therapeutic (methods)
  • Hepatic Artery
  • Immunohistochemistry
  • Liver Neoplasms, Experimental (therapy)
  • Magnetic Resonance Imaging
  • Male
  • Oligopeptides (administration & dosage, pharmacology)
  • Rats
  • Rats, Wistar

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