Abstract |
The hypothesis tested in this study was that perioperative administration of the bisphosphonate zoledronate will reduce strain protection-related calcar osteopenia and maintain functional integration of the femoral component in an ovine hemiarthroplasty model. Twelve sheep received a unilateral cemented hemiarthroplasty where six animals were given nine intravenous infusions of zoledronate (10 microg/kg) pre-, peri-, and postsurgery over 8 months. Control animals received physiological saline only. Implants remained in vivo for 9 months. Ground reaction force (GRF) was used to assess functional loading of the implanted limb, bone mineral density (BMD) was quantified using dual energy X-ray absorptiometry (DEXA). Cortical bone area, thickness, and viable osteocytes were assessed histologically. No significant differences in GRF data between groups was identified. Results demonstrated a significant drop in BMD values in the control group (9.7%) when compared with the bisphosphonate-treated group (3.2%) (p = 0.0159). Histological results showed that cortical area, thickness, and the percentage of lacunae with viable osteocytes was significantly greater in the bisphosphonate-treated group when compared with control (p = 0.002, p = 0.001, p = 0.003, respectively). The administration of zoledronate reduced cortical osteopenia in the calcar region of the proximal femur and this therapy could be used as a preventive measure to combat strain protection osteopenia and its contribution to associated aseptic loosening in total hip replacement surgery.
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Authors | Allen E Goodship, Gordon W Blunn, Jonathan Green, Melanie J Coathup |
Journal | Journal of orthopaedic research : official publication of the Orthopaedic Research Society
(J Orthop Res)
Vol. 26
Issue 5
Pg. 693-703
(May 2008)
ISSN: 1554-527X [Electronic] United States |
PMID | 18050308
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. |
Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Imidazoles
- Zoledronic Acid
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Topics |
- Animals
- Arthroplasty, Replacement, Hip
(adverse effects)
- Bone Density
(drug effects)
- Bone Density Conservation Agents
(pharmacology, therapeutic use)
- Bone Diseases, Metabolic
(diagnosis, etiology, prevention & control)
- Diphosphonates
(pharmacology, therapeutic use)
- Female
- Hip Joint
(pathology)
- Imidazoles
(pharmacology, therapeutic use)
- Locomotion
(drug effects)
- Microradiography
- Prosthesis Failure
- Random Allocation
- Sheep
- Stress, Mechanical
- Zoledronic Acid
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