A new type of MAML2 fusion in mucoepidermoid carcinoma.

Abstract

The present study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. We screened a total of 67 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas for the presence of chimeric genes. In one of these samples, a CRTC3-MAML2 fusion gene was detected. Thus, this report demonstrates the existence of a fusion of MAML2 with CREB regulated transcriptional coactivator CRTC3 additional to the already known fusion of MAML2 and CRTC1. Both gene fusions seem to result in an identical tumor phenotype and the fusion genes CRTC1-MAML2 and CRTC3-MAML2 may play a similar role in the development of mucoepidermoid carcinomas.

• Authors: André Fehr, Kerstin Röser, Klaus Heidorn, Cora Hallas, Thomas Löning, Jörn Bullerdiek
• Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer) Vol. 47 Issue 3 Pg. 203-6 (Mar 2008) ISSN: 1098-2264 [Electronic] United States
• PMID: 18050304 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2007 Wiley-Liss, Inc.

Chemical References

• CRTC1 protein, human
• CRTC3 protein, human
• DNA-Binding Proteins
• MAML2 protein, human
• Nuclear Proteins
• Oncogene Proteins, Fusion
• Trans-Activators
• Transcription Factors

Topics

• Carcinoma, Mucoepidermoid (genetics, pathology)
• DNA-Binding Proteins (genetics)
• Humans
• Nuclear Proteins (genetics)
• Oncogene Proteins, Fusion (genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Sequence Alignment
• Sequence Analysis, DNA
• Trans-Activators
• Transcription Factors (genetics)