Abstract | OBJECTIVE: METHODS AND RESULTS: CONCLUSIONS: We have demonstrated that ligand activation of PPAR-delta in ECs has a potent antiinflammatory effect, probably via a binary mechanism involving the induction of antioxidative genes and the release of nuclear corepressors. PPAR-delta agonists may have a potential for treating inflammatory diseases such as atherosclerosis and diabetes.
|
Authors | Yanbo Fan, Ying Wang, Zhihui Tang, Hong Zhang, Xiaomei Qin, Yi Zhu, Youfei Guan, Xian Wang, Bart Staels, Shu Chien, Nanping Wang |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 28
Issue 2
Pg. 315-21
(Feb 2008)
ISSN: 1524-4636 [Electronic] United States |
PMID | 18048767
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- GW 501516
- Ligands
- PPAR delta
- SOD1 protein, human
- Thiazoles
- (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid
- Thioredoxins
- Catalase
- Superoxide Dismutase
- Superoxide Dismutase-1
|
Topics |
- Catalase
(metabolism)
- Cells, Cultured
- Endothelial Cells
(immunology)
- Humans
- Inflammation
(immunology)
- Ligands
- PPAR delta
(antagonists & inhibitors, immunology, metabolism)
- Superoxide Dismutase
(metabolism)
- Superoxide Dismutase-1
- Thiazoles
(pharmacology)
- Thioredoxins
(metabolism)
- Umbilical Veins
(cytology)
- Up-Regulation
|