[Immunopathology of Lyme arthritis].

Abstract	Lyme borreliosis (Lyme disease) is the most prevalent tick-borne disease caused by spirochaetes of the Borrelia species complex. Arthritis is one of the common manifestations of B. burgdorferi infection. The pathomechanism of articular changes in Lyme arthritis has not yet been elucidated. Histopathological studies of synovia and immunological changes are similar to rheumatoid arthritis. In the early stage of inflammation B. burgdorferi interact with polynuclear granulocytes and epithelial cells, triggering production of reactive oxygen species, lipid peroxidation products and other inflammatory mediators. The imbalance between anabolic and catabolic processes in inflamed joints results in the progressive destruction of articular cartilage and disintegration of extracellular matrix. Molecular mimicry between OspA (outer surface protein A) and adhesion molecule LFA-1alpha seems to be responsible for chronic arthritis.
Authors	Sławomir A Pancewicz, Ryszard Rutkowski, Krzysztof Rutkowski, Joanna M Zajkowska, Maciej Kondrusik
Journal	Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 23 Issue 134 Pg. 141-4 (Aug 2007) ISSN: 1426-9686 [Print] Poland
Vernacular Title	Zaburzenia immunologiczne w zapaleniu stawów w boreliozie z lyme.
PMID	18044347 (Publication Type: English Abstract, Journal Article, Review)
Chemical References	Antibodies, Bacterial Antigens, Bacterial Antigens, Surface Bacterial Outer Membrane Proteins Bacterial Vaccines Cytokines Lipoproteins Lymphocyte Function-Associated Antigen-1 OspA protein Reactive Oxygen Species
Topics	Animals Antibodies, Bacterial (immunology) Antigens, Bacterial (immunology) Antigens, Surface (immunology) Arthritis, Infectious (immunology) Arthritis, Rheumatoid (immunology) Bacterial Outer Membrane Proteins (immunology) Bacterial Vaccines (immunology) Borrelia burgdorferi (immunology) Cartilage (immunology) Cytokines (immunology) Humans Inflammation (immunology) Lipoproteins (immunology) Lyme Disease (immunology) Lymphocyte Function-Associated Antigen-1 (immunology) Mice Molecular Mimicry (immunology) Reactive Oxygen Species (immunology) Synovial Membrane (immunology)

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