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An open-label study of quetiapine for delirium.

AbstractOBJECTIVE:
To evaluate the effects of quetiapine treatment in patients with delirium.
MATERIAL AND METHOD:
All patients with delirium were assessed. The diagnosis of delirium was confirmed by using the Confusion Assessment Method (CAM). Quetiapine at the dose between 25 and 100 mg/day was given for 7 days. The efficacy of quetiapine on delirium was evaluated by using the Delirium Rating Scale (DRS) and the Clinical Global Impression-Severity scale (CGI-S). The extrapyramidal side effects were assessed by using the Modified (9-item) Simpson-Angus Scale (MSAS).
RESULTS:
Twenty-two patients had delirium. Seventeen (10 males and 7 females) subjects with a mean age (SD) of 55.6 (18.6) years were included in the present study. Means (SDs) dose and duration (SD) of quetiapine treatment were 45.7 (28.7) mg/day and 6.5 (2.0) days, respectively. The DRS and CGI-S scores of days 2-7 were significantly lower than those of day 0 (p < 0. 001) for all comparisons). Only two subjects were shown to have mild tremor.
CONCLUSION:
Quetiapine within the range of 25-100 mg/day improves delirious condition within 24 hours of treatment. It is well-tolerated and has a very low propensity to induce extrapyramidal side effects. Further randomized, placebo-controlled trials are warranted.
AuthorsBenchalak Maneeton, Narong Maneeton, Manit Srisurapanont
JournalJournal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 90 Issue 10 Pg. 2158-63 (Oct 2007) ISSN: 0125-2208 [Print] Thailand
PMID18041437 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Dibenzothiazepines
  • Quetiapine Fumarate
Topics
  • Antipsychotic Agents (adverse effects, therapeutic use)
  • Basal Ganglia Diseases
  • Delirium (drug therapy, physiopathology)
  • Dibenzothiazepines (adverse effects, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Prospective Studies
  • Psychological Tests
  • Psychometrics
  • Quetiapine Fumarate
  • Treatment Outcome

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