Prevalence and clinical features of type 1.5 diabetes mellitus in children.

Abstract

AIM:

To classify children with diabetes mellitus as type 1, 1.5 or 2, based on strict criteria, and then compare their features and treatment.

METHODS:

In this retrospective study, all children with diabetes mellitus in our clinic with antibody status available (n = 120) were reclassified as type 1, 1.5 or type 2 based on status of antibodies to the pancreas and presence of obesity and/or acanthosis nigricans, and their features compared.

RESULTS:

Sixty-four percent of type 2 patients were reclassified as type 1.5. Type 1.5 patients had significantly lower BMI SDS, blood pressure and acanthosis nigricans than type 2 patients. They had a higher insulin requirement (0.82 +/- 0.44 U/kg/day) than type 1 (0.72 +/- 0.35 U/kg/day) or type 2 (0.28 +/- 0.3 U/kg/day) patients. Total cholesterol, HDL-cholesterol, ALT and AST significantly worsened from type 1 to 1.5 to type 2 patients.

CONCLUSIONS:

Type 1.5 diabetes mellitus should be considered among obese adolescents presenting as type 2, as their clinical course is more aggressive and insulin requirement higher.

• Authors: Radhika Purushothaman, Neesha Ramchandani, Irina Kazachkova, Svetlana Ten
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 20 Issue 9 Pg. 981-7 (Sep 2007) ISSN: 0334-018X [Print] Germany
• PMID: 18038707 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Glycated Hemoglobin A
• Insulin

Topics

• Acanthosis Nigricans (complications)
• Adolescent
• Autoantibodies (blood)
• Blood Pressure
• Body Mass Index
• Diabetes Mellitus (classification, drug therapy, immunology, physiopathology)
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Insulin (therapeutic use)
• Male
• Retrospective Studies