Adipokines as emerging mediators of immune response and inflammation.

Abstract

The scientific interest in the biology of white adipose tissue (WAT) has increased since the discovery of leptin in 1994. The description of the product of the gene obese (ob) demonstrated the role of adipose tissue in the physiopathology of obesity-related diseases, and helped to increase the identification of numerous other adipokines, many of a pro-inflammatory nature. It has become increasingly evident that WAT-derived adipokines can be considered as a hub between obesity-related exogenous factors, such as nutrition and lifestyle, and the molecular events that lead to metabolic syndrome, inflammatory and/or autoimmune conditions, and rheumatic diseases. In this Review, we will discuss the progress in adipokine research, focusing particular attention to the roles of leptin, adiponectin, resistin, visfatin, and other recently identified adipokines in inflammatory, autoimmune and rheumatic diseases.

• Authors: Francisca Lago, Carlos Dieguez, Juan Gómez-Reino, Oreste Gualillo
• Journal: Nature clinical practice. Rheumatology (Nat Clin Pract Rheumatol) Vol. 3 Issue 12 Pg. 716-24 (Dec 2007) ISSN: 1745-8390 [Electronic] United States
• PMID: 18037931 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Adipokines
• Adiponectin
• Leptin
• Resistin
• Nicotinamide Phosphoribosyltransferase

Topics

• Adipokines (physiology)
• Adiponectin (physiology)
• Humans
• Immune System (physiology)
• Inflammation (physiopathology)
• Leptin (physiology)
• Nicotinamide Phosphoribosyltransferase (physiology)
• Resistin (physiology)