Increased risk of oral cancer in diabetic animals is not associated with c-jun activation pathway.

Abstract

PURPOSE:

The expression of oncogenic protein c-jun was investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) Sprague-Dawley rats.

MATERIAL AND METHODS:

Thirteen diabetic and twelve normal rats developed cancer after 4-nitroquinoline-N-oxide treatment, while six diabetic and six normal animals were used as controls. The biopsies were classified pathologically from oral mucosal dysplasia to moderately differentiated oral squamous cell carcinoma (OSCC) and studied immunohistochemically using monoclonal antibody against c-jun protein.

RESULTS:

Higher c-jun levels were observed in non-cancerous and precancerous stages of normal rats compared with diabetic rats, while in different tumour stages, the expression of c-jun was practically identical for both groups.

CONCLUSION:

It seems that diabetes does not affect the c-jun N-terminal kinase (JNK)/c-jun pathway.

• Authors: Eleftherios Vairaktaris, Lambros Goutzanis, Georgios Kalokerinos, Stavros Vassiliou, Sofia Spyridonidou, Dimitris Avgoustidis, Pashalis Strantzias, Andreas Lazaris, Georgios Papageorgiou, Vassilis Ragos, Christos Yapijakis, Efstratios Patsouris
• Journal: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery (J Craniomaxillofac Surg) Vol. 35 Issue 8 Pg. 382-7 (Dec 2007) ISSN: 1010-5182 [Print] Scotland
• PMID: 18023197 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Proto-Oncogene Proteins c-jun
• 4-Nitroquinoline-1-oxide
• JNK Mitogen-Activated Protein Kinases

Topics

• 4-Nitroquinoline-1-oxide (adverse effects)
• Animals
• Biopsy
• Carcinogens
• Carcinoma, Squamous Cell (chemically induced, genetics, pathology)
• Diabetes Mellitus, Experimental (complications, genetics)
• Female
• Gene Expression Regulation, Enzymologic (genetics)
• Gene Expression Regulation, Neoplastic (genetics)
• Immunohistochemistry
• JNK Mitogen-Activated Protein Kinases (genetics)
• Mouth Mucosa (drug effects, pathology)
• Mouth Neoplasms (chemically induced, genetics, pathology)
• Neoplasm Staging
• Precancerous Conditions (chemically induced, genetics, pathology)
• Proto-Oncogene Proteins c-jun (genetics)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Risk Factors