HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Chronobiological analysis of peripheral lymphocyte dehydrogenase activities in rats with Walker 256 carcinosarcoma.

Abstract
Alpha-glycerophosphate dehydrogenase (alpha-GPD) and succinate dehydrogenase (SD) activities were investigated in lymphocytes from peripheral blood of normal rats and rats bearing the Walker 256 carcinosarcoma. Computer analysis using an original algorithm revealed a hierarchy of biorhythmic patterns of dehydrogenase activities. In all rats, mean SD activity was higher than mean alpha-GPD activity. In rats without tumor, SD and alpha-GPD activities were both higher than in rats with the Walker tumor. Biorhythm spectra for both dehydrogenases were very similar in rats with or without tumor, but tumor implantation resulted in a change of the phase relationship between alpha-GPD and SD.
AuthorsL M Strigun, E N Chirkova, G G Grigor'eva, L A Gromova, M A Yakunina, V V Nemov, A N Ivanova
JournalAnti-cancer drugs (Anticancer Drugs) Vol. 2 Issue 3 Pg. 305-10 (Jun 1991) ISSN: 0959-4973 [Print] England
PMID1802027 (Publication Type: Journal Article)
Chemical References
  • Glycerolphosphate Dehydrogenase
  • Succinate Dehydrogenase
Topics
  • Animals
  • Carcinoma 256, Walker (enzymology)
  • Female
  • Glycerolphosphate Dehydrogenase (blood)
  • Glycolysis
  • Lymphocytes (enzymology)
  • Oxygen Consumption (physiology)
  • Periodicity
  • Rats
  • Succinate Dehydrogenase (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: