Abstract |
A detailed study of the combined effect of suramin, MK 436 (5-nitroimidazole) and Cymelarsan ( melaminylthioarsenate) was investigated in the murine CNS- trypanosomiasis model. Using a combination of Cymelarsan and MK 436 without preliminary suramin, complete cures were obtained with a 2 day treatment of 15.0 mg/kg MK 436 and 5.0 mg/kg Cymelarsan. If the MK 436 was reduced to 10 mg/kg then 4 consecutive daily treatments were required. If the Cymelarsan was reduced to 2.5 mg/kg either a 3 day treatment in combination with 15.0 mg/kg or a 4 day treatment with 10 mg/kg MK 436 was necessary. Utilizing the single suramin (20 mg/kg) dose followed by combined MK 436/ Cymelarsan a 2 day treatment with 10 mg/kg (or twice daily 5.0 mg/kg) MK 436 and 2.5 mg/kg Cymelarsan gave complete cures. Maximum cure rate for suramin followed by a one day treatment with 15 mg/kg MK 436 and 5.0 mg/kg Cymelarsan was 4/6 mice, indicating that a one day treatment regimen might be possible with slightly increases dose rates of the two trypanocides. A two day treatment period for CNS- trypanosomiasis is therefore feasible with the dose levels used in these experiments provided a combination chemotherapeutic regimen of suramin, MK 436, Cymelarsan are employed.
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Authors | F W Jennings |
Journal | Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)
(Trop Med Parasitol)
Vol. 42
Issue 3
Pg. 157-60
(Sep 1991)
ISSN: 0177-2392 [Print] Germany |
PMID | 1801135
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Arsenicals
- Nitroimidazoles
- Trypanocidal Agents
- MK 436
- Suramin
- melaminylthioarsenate
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Topics |
- Animals
- Arsenicals
(therapeutic use)
- Brain Diseases
(drug therapy)
- Disease Models, Animal
- Drug Therapy, Combination
- Female
- Mice
- Nitroimidazoles
(therapeutic use)
- Suramin
(therapeutic use)
- Trypanocidal Agents
(therapeutic use)
- Trypanosoma brucei brucei
- Trypanosomiasis, African
(drug therapy)
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