Abstract | BACKGROUND: METHODS: We enrolled 125 patients in a cross-sectional study and 28 patients in a longitudinal study and examined visceral and subcutaneous fat thickness, hepatic steatosis score, and biochemical parameters. In the longitudinal study, the influence of weight change on fat distribution and hepatic steatosis was investigated. RESULTS: In the cross-sectional study, the severity of hepatic steatosis showed a significant positive correlation with body mass index, visceral fat thickness, serum albumin, alanine aminotransferase (ALT), cholinesterase, fasting insulin, and the homeostasis model assessment of insulin resistance. ALT, visceral fat thickness, and serum albumin were independent factors for hepatic steatosis. In the longitudinal study, visceral fat thickness fluctuated closely with changes in body weight, and had the strongest relationship with the change of hepatic steatosis by multivariate analysis. CONCLUSIONS: Visceral fat was the most important factor for the development of hepatic steatosis. Visceral fat thickness can be measured by sonography easily, noninvasively, and repeatedly for assessment of central obesity and monitoring of the efficacy of treatment of nonalcoholic fatty liver disease.
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Authors | Masahiko Koda, Manri Kawakami, Yoshikazu Murawaki, Miho Senda |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 42
Issue 11
Pg. 897-903
(Nov 2007)
ISSN: 0944-1174 [Print] Japan |
PMID | 18008034
(Publication Type: Journal Article)
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Chemical References |
- Serum Albumin
- Alanine Transaminase
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Topics |
- Adult
- Aged
- Alanine Transaminase
(blood)
- Body Mass Index
- Body Weight
- Cross-Sectional Studies
- Fatty Liver
(diagnostic imaging, pathology, physiopathology)
- Female
- Humans
- Insulin Resistance
- Intra-Abdominal Fat
(diagnostic imaging)
- Longitudinal Studies
- Male
- Middle Aged
- Serum Albumin
- Subcutaneous Fat, Abdominal
(diagnostic imaging)
- Ultrasonography
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