Abstract | BACKGROUND AND OBJECTIVE:
Neutropenic enterocolitis (NE) is a complication arising in neutropenic patients with acute leukemia or solid tumours while treated with intensive chemotherapy. The optimal therapeutic procedures have not been well established. PATIENTS AND METHOD: Seven cases of NE diagnosed and treated in a tertiary hospital between 2000 and 2007 are described. Their clinico- biological characteristics, therapeutic procedures and evolution were analysed retrospectively. RESULTS: Five of the patients were males, their median age was 39 years. Acute myeloblastic leukemia was the most frequent diagnosis (5 cases). Two other patients had received an stem cell transplantation. Abdominal pain was present in all patients, diarrhoea in 6, and fever in 5. Microorganisms were isolated from blood cultures in 4 cases (Clostridium septicum, Escherichia coli, Pseudomonas aeruginosa and Aeromonas hydrophila). Abnormal mural thickening of the caecum was observed in the 6 cases in which a computed tomography scan could be performed. The median mural thickness at its maximum section was 11 mm (range: 8-16). All patients first received medical treatment with wide spectrum antibiotics and intestinal rest, and abdominal surgery was indicated in 6 cases after a median time from first symptom of 4 days (range: 0-12). NE was confirmed histologically in all 6 patients. Five patients required admission in Intensive Care Unit and 2 (29%) died as a result of NE. CONCLUSIONS:
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Authors | Montserrat Batlle, Ferran Vall-Llovera, Jordi Bechini, Ignasi Camps, Pilar Marcos, Susana Vives, Albert Oriol, Josep-Maria Ribera |
Journal | Medicina clinica
(Med Clin (Barc))
Vol. 129
Issue 17
Pg. 660-3
(Nov 10 2007)
ISSN: 0025-7753 [Print] Spain |
Vernacular Title | Enterocolitis neutropénica en adultos con leucemia aguda o receptores de un trasplante de progenitores hematopoyéticos: estudio de 7 casos. |
PMID | 18005634
(Publication Type: Case Reports, Comparative Study, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Antineoplastic Agents
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Topics |
- Abdominal Pain
(etiology)
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Enterocolitis, Neutropenic
(chemically induced, diagnostic imaging, drug therapy, etiology, mortality, pathology, surgery)
- Female
- Humans
- Intensive Care Units
- Leukemia, Myeloid, Acute
(complications, drug therapy)
- Male
- Middle Aged
- Retrospective Studies
- Stem Cell Transplantation
(adverse effects)
- Tomography, X-Ray Computed
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