Abstract | OBJECTIVE: DESIGN: A population-based case-control study. SETTING: POPULATION: METHODS: Information on drug exposure and background variables for the mothers were collected from antenatal logbooks, discharge summaries, and structured questionnaires completed by the mothers at the time of HCCSCA registration. MAIN OUTCOME MEASURES:
Congenital abnormalities detected at termination of pregnancy, at birth or until 3 months of age according to CBZ, PB, PHT, or PRI exposure at 5-12 weeks from first day of the last menstrual period (LMP), stratified by folic acid supplementation. RESULTS: Compared with children unexposed to AEDs and folic acid, the odds ratio of congenital abnormalities was 1.47 (95% CI 1.13-1.90) in children exposed to AEDs without folic acid supplementation and 1.27 (95% CI 0.85-1.89) for children exposed to AEDs with folic acid supplementation. CONCLUSION: The results indicate that the risk of congenital abnormalities in children exposed in utero to CBZ, PB, PHT, and PRI is reduced but not eliminated by folic acid supplementation at 5-12 weeks from LMP. The statistical precision in our study is limited due to rarity of the exposures, and further studies are needed.
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Authors | D Kjaer, E Horvath-Puhó, J Christensen, M Vestergaard, A E Czeizel, H T Sørensen, J Olsen |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 115
Issue 1
Pg. 98-103
(Jan 2008)
ISSN: 1471-0528 [Electronic] England |
PMID | 17999694
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Folic Acid
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Topics |
- Abnormalities, Drug-Induced
(etiology, prevention & control)
- Adult
- Anticonvulsants
(adverse effects)
- Case-Control Studies
- Epilepsy
(drug therapy)
- Female
- Folic Acid
(administration & dosage)
- Humans
- Male
- Pregnancy
- Pregnancy Complications
(drug therapy)
- Pregnancy Trimester, First
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