Impact of terlipressin on renal graft function.

Abstract

To assess the effect of a bolus of terlipressin in brain-dead donors with shock refractory to norepinephrine, a retrospective study was conducted in a 16-bed intensive care unit of a university hospital. Twenty brain-dead donors were treated with norepinephrine within the study period. Nine of these donors developed persisting hypotension (MAP < 65 mmHg) not responding to fluid loading and high dose of norepinephrine. They were then treated with a single bolus of terlipressin (1 mg). This resulted in a MAP rise from 58 +/- 10 to 93 +/- 20 mmHg (P = 0.009). One month after transplantation, no differences were observed in serum creatinine levels of the recipients who received a renal transplant extracted from donors responding or not to norepinephrine (138 +/- 43 vs. 137 +/- 43 microM; P = 0.95). The liver function was similar in both groups. Within the limitations of this study, a single bolus of terlipressin in norepinephrine-resistant vasodilatory shock donors does not affect the renal and liver graft quality in the recipients.

• Authors: Valéry Blasco, Marc Leone, Alain Geissler, François Antonini, Jacques Albanèse, Claude Martin
• Journal: Shock (Augusta, Ga.) (Shock) Vol. 29 Issue 6 Pg. 667-9 (Jun 2008) ISSN: 1073-2322 [Print] United States
• PMID: 17998885 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antihypertensive Agents
• Lypressin
• Terlipressin
• Creatinine
• Norepinephrine

Topics

• Adult
• Aged
• Antihypertensive Agents (administration & dosage)
• Brain Death (blood, physiopathology)
• Creatinine (blood)
• Female
• Graft Survival (drug effects)
• Humans
• Hypotension (blood, chemically induced)
• Kidney (metabolism, physiopathology)
• Kidney Transplantation
• Liver (metabolism, physiopathology)
• Lypressin (administration & dosage, analogs & derivatives)
• Male
• Middle Aged
• Norepinephrine (administration & dosage, adverse effects)
• Recovery of Function (drug effects)
• Retrospective Studies
• Shock (blood, chemically induced)
• Terlipressin
• Transplantation, Homologous