Abstract | BACKGROUND: METHODS: We studied 53 consecutive donor-recipient pairs to determine the impact of KIR genotypes and their bidirectional KIR interactions. RESULTS: All activating KIR genes in donors were important factors for determining outcome in a manner distinctive for each gene studied. Specifically, the 2DS2 gene and the 2DS4*003 allele were closely correlated with acute GVHD. The 2DS1 gene was associated with a better long-term survival, even if present only in the donor and not the recipient. The 2DS3-2DS5 dual genes were more often involved in a variety of transplant-related complications. CONCLUSIONS: In conclusion, these factors may help predict transplant outcomes and aid in our understanding of immunogenetic specificity.
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Authors | Hee-Je Kim, Young Choi, Woo-Sung Min, Tai-Gyu Kim, Byung-Sik Cho, Sung-Yong Kim, Ki-Sung Eom, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee, Chun-Choo Kim |
Journal | Transplantation
(Transplantation)
Vol. 84
Issue 9
Pg. 1082-91
(Nov 15 2007)
ISSN: 0041-1337 [Print] United States |
PMID | 17998861
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Cytomegalovirus Infections
(epidemiology)
- Gene Frequency
- Genotype
- Graft Survival
- Graft vs Host Disease
(epidemiology, immunology)
- Hematopoietic Stem Cell Transplantation
- Histocompatibility Testing
- Humans
- Killer Cells, Natural
(immunology)
- Leukemia, Myeloid, Acute
(therapy)
- Lymphocyte Activation
- Postoperative Complications
(epidemiology)
- Receptors, KIR
(genetics, immunology)
- Siblings
- Transplantation Conditioning
- Transplantation, Homologous
- Treatment Outcome
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