Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Nine patients were enrolled in the study. Mean age was 55 + 14.2 years, being 5 male (55.5%) and 4 (44.5%) female patients. All of them presented functional class III-IV of the New York Heart Association (NYHA), and 5 (55.5%) received dobutamine. All of them presented initial creatinine > 1.4 mg/dl. The mean tonicity of the solution was 4.39% + 0.018% (2.5% to 7.5%) and the duration of treatment was 4.9 days + 4.1 days (1-15 days). There were no severe adverse effects; none of the patients presented clinical worsening or neurologic disorders; hypokalemia occurred in 4 cases (44.5%). The comparison of the variables before and after treatment showed a decrease in urea (105 mg/dl + 74.8 mg/dl vs. 88 mg/dl + 79.4 mg/dl; p = 0.03) and increase in the urinary volume (1,183 ml/day vs. 1,778 ml/day; p = 0.03); there was no tendency to creatinine decrease (2.0 mg/dl + 0.8 mg/dl vs. 1.7 mg/dl + 1.0 mg/dl; p = 0.08). Despite the elevation in sodium levels (131 mEq/l + 2.8 mEq/l vs. 134 mEq/l + 4.9 mEq/l) and weight decrease (69.5 kg + 18.6 kg vs. 68.2 kg + 17.1 kg), there was no statistically significant difference. CONCLUSION:
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Authors | Victor Sarli Issa, Fernando Bacal, Sandrigo Mangini, Rodrigo Moreno Dias Carneiro, Cristiano Humberto Naves de Freitas Azevedo, Paulo Roberto Chizzola, Silvia Moreira Ayub Ferreira, Edimar Alcides Bocchi |
Journal | Arquivos brasileiros de cardiologia
(Arq Bras Cardiol)
Vol. 89
Issue 4
Pg. 251-5
(Oct 2007)
ISSN: 1678-4170 [Electronic] Brazil |
PMID | 17992382
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Biomarkers
- Cardiotonic Agents
- Diuretics
- Saline Solution, Hypertonic
- Dobutamine
- Furosemide
- Urea
- Sodium
- Creatinine
- Potassium
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Topics |
- Biomarkers
(blood)
- Cardiotonic Agents
(therapeutic use)
- Creatinine
(blood)
- Diuretics
(therapeutic use)
- Dobutamine
(therapeutic use)
- Female
- Furosemide
(therapeutic use)
- Heart Failure
(blood, drug therapy)
- Humans
- Hypokalemia
(etiology)
- Hyponatremia
(blood, drug therapy)
- Male
- Middle Aged
- Potassium
(blood)
- Renal Insufficiency
(prevention & control)
- Saline Solution, Hypertonic
(adverse effects, therapeutic use)
- Severity of Illness Index
- Sodium
(blood)
- Time Factors
- Treatment Outcome
- Urea
(blood)
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