[Local therapy of grade IIa burns: efficacy and tolerability of a new hydrosome wound gel for the local treatment of grade IIa burns as compared with silver sulfadiazine ointment].

Abstract

BACKGROUND:

A new hydrosome wound gel is based on a new mechanism of action. It contains hydrosomes that penetrate to the wound bed and supply the wound with phospholipids, which are identical to membrane phospholipids of human cells. In this manner it supports the proliferative processes during wound healing.

PATIENTS AND METHODS:

In a randomized, controlled, intraindividual comparative study of 47 patients with grade IIa burns, the hydrosome wound gel was tested against silver sulfadiazine cream. Digital pictures of the burn wounds were taken daily, and the wounds were analyzed in terms of their reepithelization rate.

RESULTS:

Wounds receiving the hydrosome wound gel healed 1.5-2 days faster than wounds treated with sulfadiazine cream (9.9+/-4.5 days vs. 11.3+/-4.9 days, p=0.015). In 66% of the patients, faster epithelization was observed with the hydrosome wound gel treatment. The hydrosome gel guaranteed secure prophylaxis against infection, and it was well tolerated and easy to apply.

CONCLUSION:

In this study, the treatment of grade IIa burn wounds with hydrosome wound gel led to faster wound closure compared with treatment with sulfadiazine cream. Therefore, hydrosome gel represents a good alternative to sulfadiazine cream.

• Authors: J Hauser, O Rossbach, S Langer, P Vogt, G Germann, H U Steinau, K Reimer, M Hopp, B Langer-Brauburger, B Bosse, H H Homann
• Journal: Der Unfallchirurg (Unfallchirurg) Vol. 110 Issue 11 Pg. 988-94 (Nov 2007) ISSN: 0177-5537 [Print] Germany
• Vernacular Title: Lokale Behandlung von Grad-IIa-Verbrennungen : Wirksamkeit und Verträglichkeit eines neuartigen hydrosomalen Wundgels im Vergleich zu Silbersulfadiazin-Creme.
• PMID: 17989948 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Local
• Liposomes
• Repithel
• Hydrogel, Polyethylene Glycol Dimethacrylate
• Povidone-Iodine
• Povidone
• Silver Sulfadiazine

Topics

• Adolescent
• Adult
• Aged
• Anti-Infective Agents, Local (administration & dosage)
• Burns (drug therapy)
• Child
• Child, Preschool
• Humans
• Hydrogel, Polyethylene Glycol Dimethacrylate (administration & dosage)
• Liposomes
• Middle Aged
• Povidone (administration & dosage)
• Povidone-Iodine (administration & dosage)
• Silver Sulfadiazine (administration & dosage)
• Wound Healing (drug effects)
• Wound Infection (prevention & control)