Four hundred and sixty-nine pregnant women with high hemorrhagic risk factors including twin pregnancy,
polyhydramnios,
fetal macrosomia,
placenta previa were planned
cesarean section. A total of 457 pregnant women were divided into 3 groups by operation indications. There were 239 cases of
fetal macrosomia, 145 cases of twin pregnancy and
polyhydramnios, and 73 cases of
placenta previa. Three kinds of hysterotonics were used randomly in each group. Group
oxytocin (O): 20 U
oxytocin injected into the uterine plus 20 U
oxytocin intravascularly, 152 women; Group
oxytocin +
hemabate (O + H): 20 U
oxytocin and 250 microg hemabat injected into the uterine, 192 women; group H: 250 microg hemabat, injected into the uterine, 125 women. The amount of
bleeding during the operation and within 2-hour after delivery were measured. The side effect of each group was observed.
RESULTS: The amount of
bleeding during
cesarean section in group O was (445 +/- 262) ml, in group O + H (332 +/- 218) ml, and in group H (375 +/- 265) ml. There was an extremely significant difference between group O and group O + H (P < 0.01). The amount of
bleeding within 2 hours after delivery in group O was (176 +/- 193) ml, in group O + H was (110 +/- 114) ml, and in group H was (124 +/- 103) ml. There was a significant difference between groups O, O + H and H. Among the 469 women, 31 had total amount of
bleeding more than 1000 ml during operation and within 2 hours after delivery. 48% (15 women) were in group O, 23% in group O + H and 29% in group H. The total amount of
bleeding in group O was much more than group O + H and group H in the group of
fetal macrosomia (P < 0.01, P < 0.01). Similar results were found in the group of twin pregnancy and
polyhydramnios (P < 0.01, P < 0.01). The total amount
bleeding in group O + H was much less than group O in the group of
placenta previa (P < 0.05). There were 5% (12) pregnant women whose total amount of
bleeding was >/= 1000 ml in the group of
fetal macrosomia, 8% (11) in the group of twin pregnancy, 11% (8) in the group of
placenta previa. No
hysterectomy was done among the women. The incidence of side effects in the three groups was 2.6%, 11.5% and 7.0% respectively.
Vomiting was frequently seen in the latter two groups, but recovered soon without treatment.
CONCLUSION: Hemabat can significantly reduce the amount of
bleeding during the
cesarean section in pregnant women with high hemorrhagic risk factors and can be used with
oxytocin as firstline medicine to prevent
hemorrhage during and after delivery.