Abstract | PURPOSE: EXPERIMENTAL DESIGN: Antibody microarrays were used to identify proteins consistently differentially expressed across three pairs of cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines. Immunoblotting was used to confirm observed alteration of protein expression. The protein expression was further evaluated by immunohistochemical staining using tissue microarrays containing various human normal and malignant tissues and 164 surgical specimens derived from primary and recurrent ovarian cancer patients who underwent primary debulking surgery followed by standard chemotherapeutic regimen. RESULTS: CONCLUSION:
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Authors | Jin Song, Ie-ming Shih, Ritu Salani, Daniel W Chan, Zhen Zhang |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 13
Issue 22 Pt 1
Pg. 6842-9
(Nov 15 2007)
ISSN: 1078-0432 [Print] United States |
PMID | 17982121
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Annexins
- Antineoplastic Agents
- Cisplatin
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Annexins
(analysis, metabolism)
- Antineoplastic Agents
(pharmacology)
- Cell Line, Tumor
- Cisplatin
(pharmacology)
- Drug Resistance, Neoplasm
- Female
- Humans
- Middle Aged
- Neoplasm Recurrence, Local
(metabolism)
- Ovarian Neoplasms
(metabolism, pathology)
- Prognosis
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